Flag Counter
AKILLI SİSTEMLER VE UYGULAMALARI DERGİSİ
JOURNAL OF INTELLIGENT SYSTEMS WITH APPLICATIONS
J. Intell. Syst. Appl.
E-ISSN: 2667-6893
Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Challenges in Lung and Respiratory Sound Processing: Quantity and Quality of Available Data

Akciğer ve Solunum Sesi İşlemedeki Zorluklar: Mevcut Verilerin Niceliği ve Niteliği

How to cite: Kuntalp D. Challenges in lung and respiratory sound processing: quantity and quality of available data. Akıllı Sistemler ve Uygulamaları Dergisi (Journal of Intelligent Systems with Applications) 2023; 6(2): 44-54.

Full Text: PDF, in English.

Total number of downloads: 123

Title: Challenges in Lung and Respiratory Sound Processing: Quantity and Quality of Available Data

Abstract: Respiratory diseases, both acute and chronic, are widespread due to exposure to harmful substances in the environment, workplace, and through personal behaviors. Furthermore, the COVID-19 pandemic has led to both short-term and long-term lung damage in survivors. Therefore, accurate identification of chronic respiratory diseases, in particular, is vital for effective management and treatment. Auscultation, the practice of listening to respiratory sounds, plays a crucial role in diagnosing respiratory diseases. By accurately interpreting these sounds, complemented by other clinical findings, specialists can make reliable diagnoses with minimal errors. However, the effectiveness of auscultation is heavily influenced by the doctor's experience and environmental noise. To address these limitations, automatic classification of respiratory sounds recorded with a digital stethoscope using expert software has emerged as a popular research area. This approach eliminates the reliance on subjective interpretation by specialists. Unfortunately, as with many biomedical signals, researchers face significant challenges. The most pressing issue is the need for high-quality, accurately labeled, and extensive lung and respiratory sound datasets. Additionally, removing noise that distorts these sound signals is another major obstacle. This brief review aims to delve into these two primary challenges and provide examples of potential solutions from relevant literature.

Keywords: lung sound, respiratory sound, data augmentation, noise removal


Başlık: Akciğer ve Solunum Sesi İşlemedeki Zorluklar: Mevcut Verilerin Niceliği ve Niteliği

Özet: Çevresel faktörler, işyeri koşulları ve kişisel alışkanlıklar nedeniyle hem akut hem de kronik solunum hastalıkları sıklıkla görülmektedir. COVID-19 pandemisi ise, uzun vadeli sağlık sorunlarına yol açarak solunum sağlığı üzerinde ek bir yük oluşturmuştur. Bu bağlamda, özellikle kronik solunum hastalıklarının doğru teşhisi ve etkili yönetimi büyük önem taşımaktadır. Solunum seslerinin dinlenmesi (auskultasyon), geleneksel olarak solunum hastalıklarının teşhisinde kullanılan bir yöntemdir. Ancak, bu yöntemin etkinliği, hekimin deneyimine ve çevresel faktörlere bağlı olarak değişkenlik gösterebilmektedir. Bu nedenle, dijital stetoskoplarla kaydedilen solunum seslerinin bilgisayar ortamında otomatik olarak analiz edilmesi, daha objektif ve güvenilir bir teşhis yöntemi olarak öne çıkmaktadır. Ancak, bu alandaki çalışmaların ilerlemesinin önünde bazı önemli zorluklar bulunmaktadır. Bunlardan ilki, doğru etiketlenmiş ve kapsamlı solunum sesi veri setlerinin yetersizliği, ikincisi ise solunum seslerindeki gürültüyü etkili bir şekilde giderme ihtiyacıdır. Bu çalışmada, bu iki temel zorluğa değinilerek, literatürdeki olası çözüm önerileri incelenecektir.

Anahtar kelimeler: solunum sesi, akciğer sesi, veri artırma, gürültü giderme


Bibliography:
  • Soriano JB (+ 231 colleagues), et al. Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet Respiratory Medicine 2020; 8(6): 585-596.
  • Narin A, Pamuk Z. Effect of different batch size parameters on predicting of COVID19 cases. Journal of Intelligent Systems with Applications 2020; 3(2): 69-72.
  • Narin A, Isler Y. Detection of new coronavirus disease from chest x-ray images using pre-trained convolutional neural networks. Journal of the Faculty of Engineering and Architecture of Gazi University 2021; 36(4): 2095-2107.
  • Labaki WW, Han MK. Chronic respiratory diseases: a global view. The Lancet Respiratory Medicine 2020; 8(6): 531-533.
  • Labaki WW, Han MK. Improving detection of early chronic obstructive pulmonary disease. Annals of the American Thoracic Society 2018; 15(Supplement 4): S243-S248.
  • Martinez CH, Mannino DM, Jaimes FA, Curtis JL, Han MK, Hansel NN, Diaz AA. Undiagnosed obstructive lung disease in the United States. Associated factors and long-term mortality. Annals of the American Thoracic Society 2015; 12(12): 1788-1795.
  • Boehm A, Pizzini A, Sonnweber T, Loeffler-Ragg J, Lamina C, Weiss G, Tancevski I. Assessing global COPD awareness with Google Trends. European Respiratory Journal 2019; 53: 1900351.
  • Talley NJ, O'COnnor S. Clinical Examination: A Systematic Guide to Physical Diagnosis. Elsevier Health Sciences, 6th edition, 2009.
  • Wolrd Health Organization. Density of physicians, 2017.
  • Troncoso A, Ortega JA, Seepold R, Madrid NM. Non-invasive devices for respiratory sound monitoring. Procedia computer science 2021; 192: 3040-3048.
  • Sun Y, Wong AKC, Kamel MS. Classification of imbalanced data: A review. International Journal of Pattern Recognition and Artificial Intelligence 2009; 23(4): 687-719.
  • Dong X, Yin B, Cong Y, Du Z, Huang X. Environment sound event classification with a two-stream convolutional neural network. IEEE Access 2020; 8: 125714-125721.
  • Alzubaidi L, Zhang J, Humaidi AJ, Al-Dujaili A, Duan Y, Al-Shamma O, Santamaría J, Fadhel MA, Al-Amidie M, Farhan L. Review of deep learning: concepts, CNN architectures, challenges, applications, future directions. Journal of Big Data 2021; 8: 53.
  • Zhao YX, Li Y, Wu N. Data augmentation and its application in distributed acoustic sensing data denoising. Geophysical Journal International 2022; 228(1): 119-133.
  • Abeber J. A review of deep learning based methods for acoustic scene classification. Applied Sciences 2020; 10(6): app10062020.
  • Bahmei B, Birmingham E, Arzanpour S. CNN-RNN and data augmentation using deep convolutional generative adversarial network for environmental sound classification. IEEE Signal Processing Letters 2022; 29: 682-686.
  • Feurer M, Hutter F. Hyperparameter optimization. Book chapter in: Automated Machine Learning: Methods, Systems, Challenges, 2019, pp. 3-33.
  • Ravizza A, De Maria C, Di Pietro L, Sternini F, Audenino AL, Bignardi C. Comprehensive review on current and future regulatory requirements on wearable sensors in preclinical and clinical testing. Frontiers in Bioengineering and Biotechnology 2019; 7: 313.
  • Tettey F, Parupelli SK, Desai S. A review of biomedical devices: classification, regulatory guidelines, human factors, software as a medical device, and cybersecurity. Biomedical Materials & Devices 2024; 2(1): 316-341.
  • Isler Y, Olcuoglu LT, Yeniad M. Data security and privacy issues of implantable medical devices. Natural and Engineering Sciences 2018; 3(3), 12-22.
  • Richards M. The collection, linking and use of data in biomedical research and health care: ethical issues. Nuffield Council of Bioethics, 2015.
  • Lourenco A, da Silva HP, Carreiras C, Alves AP, Fred ALN. A web-based platform for biosignal visualization and annotation. Multimedia Tools and Applications 2014; 70: 433-460.
  • Huang Y, Gottardo R. Comparability and reproducibility of biomedical data. Briefings in Bioinformatics 2013; 14(4): 391-401.
  • Wang Y, Liu L, Wang C. Trends in using deep learning algorithms in biomedical prediction systems. Frontiers in Neuroscience 2023; 17: 1256351.
  • Kalaivani K, Kshirsagarr PR, Sirisha Devi J, Bandela SR, Colak I, Nageswara Rao, J, Rajaram A. Prediction of biomedical signals using deep learning techniques. Journal of Intelligent & Fuzzy Systems 2023; 44(6): 9769-9782.
  • Taye MM. Understanding of machine learning with deep learning: architectures, workflow, applications and future directions. Computers 2023; 12(5): 91.
  • Degirmenci M, Yuce YK, Isler Y. Motor imaginary task classification using statistically significant time domain and frequency domain EEG features. Journal of Intelligent Systems with Applications 2022; 5(1): 49-54.
  • Sayilgan E, Yuce YK, Isler Y. Investigating the effect of flickering frequency pair and mother wavelet selection in steady-state visually-evoked potentials on two-command brain-computer interfaces. IRBM 2022; 43(6): 594-603.
  • Uzun R, Isler Y, Toksan M. Use of support vector machines to predict the success of wart treatment methods. 2018 Innovations in Intelligent Systems and Applications Conference (ASYU), 2018.
  • Sayilgan E, Yuce YK, Isler Y. Evaluating steady-state visually evoked potentials-based brain-computer interface system using wavelet features and various machine learning methods. Book chapter in: Brain-Computer Interface, InTech Publications, 2021.
  • Penzel T, B. Kemp B, Klosch G, Schlogl A, Hasan J, Varri A, Korhonen I. Acquisition of biomedical signals databases. IEEE Engineering in Medicine and Biology Magazine 2001; 20(3): 25-32.
  • Pramono RXA, Bowyer S, Rodriguez-Villegas E. Automatic adventitious respiratory sound analysis: A systematic review. PloS One 2017; 12(5): e0177926.
  • https://paperswithcode.com/sota/audio-classification-on-icbhi-respiratory
  • https://www.kaggle.com/datasets/praveengovi/coronahack-respiratory-sound-dataset
  • https://www.kaggle.com/datasets/shivam316/respiratory-disease-dataset-processed-audio-files
  • https://www.kaggle.com/datasets/arashnic/lung-dataset
  • https://www.kaggle.com/datasets/mohammedtawfikmusaed/asthma-detection-dataset-version-2
  • https://www.thesimtech.org/av-stimuli
  • https://data.mendeley.com/datasets/fr7zvy8j5s/1
  • Horwath JP, Zakharov DN, Megret R, Stach EA. Understanding important features of deep learning models for segmentation of high-resolution transmission electron microscopy images. Computational Materials 2020; 6(1): 108.
  • Abayomi-Alli OO, Damasevicius R, Qazi A, Adedoyin-Olowe M, Misra S. Data augmentation and deep learning methods in sound classification: A systematic review. Electronics 2022; 11(22): 3795.
  • Rocha BM, Filos D, Mendes L, Serbes G, Ulukaya S, Kahya YP, Jakovljevic N, Turukalo TL, Vogiatzis IM, Perantoni E, Kaimakamis E, Natsiavas P, Oliveira A, Jacome C, Marques A, Maglaveras N, Paiva RP, Chouvarda I, de Carvalho P. An open access database for the evaluation of respiratory sound classification algorithms. Physiological Measurement 2019; 40(3): 035001.
  • Nguyen T, Pernkopf F. Lung sound classification using co-tuning and stochastic normalization. IEEE Transactions on Biomedical Engineering 2022; 69(9): 2872-2882.
  • Gairola S, Tom F, Kwatra N, Jain M. RespireNet: A deep neural network for accurately detecting abnormal lung sounds in limited data setting. 2021 IEEE 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021, pp. 527-530.
  • Geron, Hands-On Machine Learning with Scikit-Learn Keras and Tensorflow: Concepts Tools and Techniques to Build Intelligent Systems, O' Reilly Media, 2019.
  • Berna A, Alcin OF, Sengur A. A lung sound classification system based on data augmenting using ELM-Wavelet-AE. Turkish Journal of Science and Technology 2022; 17(1): 79-88.
  • Ma Y, Xu X, Li Y. LungRN+NL: An improved adventitious lung sound classification using non-local block resnet neural network with mixup data augmentation. Interspeech, 2020, pp. 2902-2906.
  • Araujo T, Aresta G, Mendonça L, Penas S, Maia C, Carneiro A, Mendonca AM, Campliho A. Data augmentation for improving proliferative diabetic retinopathy detection in eye fundus images. IEEE Access 2020; 8: 182462-182474.
  • Qian Y, Hu H, Tan T. Data augmentation using generative adversarial networks for robust speech recognition. Speech Communication 2019; 114: 1-9.
  • Ramesh V, Vatanparvar K, Nemati E, Nathan V, Rahman MM, Kuang J. CoughGAN: Generating synthetic coughs that improve respiratory disease classification. 2020 IEEE 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020, pp. 5692-5688.
  • Mertes S, Baird A, Schiller D, Schuller BW, Andre E. An evolutionary-based generative approach for audio data augmentation. 2020 IEEE 22nd International Workshop on Multimedia Signal Processing (MMSP), 2020.
  • Jayalakshmy S, Priya L, Sudha GF. Synthesis of respiratory signals using conditional generative adversarial networks from scalogram representation. Book chapter in: Generative adversarial networks for image-to-image translation. Academic Press, 2021, pp. 161-183.
  • Nishant Y, Rajan B. Data augmentation using GAN for sound based COVID 19 diagnosis. 2021 IEEE 11th international conference on intelligent data acquisition and advanced computing systems: technology and applications (IDAACS), 2021, pp. 606-609.
  • Saldanha J, Chakraborty S, Patil S, Kotecha K, Kumar S, Nayyar A. Data augmentation using variational autoencoders for improvement of respiratory disease classification. Plos One 2022; 17(8): e0266467.
  • Soni PN, Shi S, Sriram PR, Ng AY, Rajpurkar P. Contrastive learning of heart and lung sounds for label-efficient diagnosis. Patterns 2022; 3(1): 100400.
  • Singh D, Singh BK, Behera AK. Design of multi-ensemble hybrid filtering approach for removal of heart sound from lung auscultations. Journal of Information and Optimization Sciences 2024; 45(3): 785-793.
  • Wang H, Wang LY. Multi-sensor adaptive heart and lung sound extraction. 2003 IEEE Sensors, 2003, pp. 1096-1099.
  • Pouyani MF, Vali M, Ghasemi MA. Lung sound signal denoising using discrete wavelet transform and artificial neural network. Biomedical Signal Processing and Control 2022; 72: 103329.
  • Hossain I, Moussavi Z. An overview of heart-noise reduction of lung sound using wavelet transform based filter. Proceedings of the IEEE 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, IEEE Cat. No. 03CH37439, 2003.
  • Mondal A, Bhattacharya PS, Saha G. Reduction of heart sound interference from lung sound signals using empirical mode decomposition technique. Journal of Medical Engineering & Technology 2011; 35(6-7): 344-353.
  • Singh D, Singh BK, Behera AK. Comparative analysis of Lung sound denoising technique. 2020 IEEE First International Conference on Power, Control and Computing Technologies (ICPC2T), 2020, pp. 406-410.
  • Yamuna KS, Thirunavukkarasu S, Manjunatha B, Karthikeyan B. Elimination of heart sound from respiratory sound using adaptive variational mode decomposition for pulmonary diseases diagnosis. Journal of Intelligent & Fuzzy Systems 2024; 46(2): 3649-3657.
  • Sangeetha B, Periyasamy R. Heart sound noise separation from lung sound based on enhanced variational mode decomposition for diagnosing pulmonary diseases. Biomedical Engineering: Applications, Basis and Communications 2024; 36(01): 2350035.
  • Ghaderi F, Mohseni HR, S. Sanei S, Localizing heart sounds in respiratory signals using singular spectrum analysis. IEEE Transactions on Biomedical Engineering 2011; 58(12): 3360-3367.
  • Pourazad MT, Moussavi Z, Thomas G. Heart sound cancellation from lung sound recordings using time-frequency filtering. Medical and Biological Engineering and Computing 2006; 44: 216-225.
  • Iyer VK, Ramamoorthy PA, Fan H, Ploysongsang Y. Reduction of heart sounds from Lung sounds by adaptive filtering. IEEE Transactions on Biomedical Engineering 1986; 33(12): 1141-1148.
  • Molaie M, Jafari S, Moradi MH, Sprott JC, Golpayegani SMRH. A chaotic viewpoint on noise reduction from respiratory sounds. Biomedical Signal Processing and Control 2014; 10: 245-249.
  • Grooby E, Sitaula C, Fattahi D, Sameni R, Tan K, Zhou L, King A, Ramanathan A, Malhotra A, Dumont G, Marzbanrad F. Noisy neonatal chest sound separation for high-quality heart and lung sounds. IEEE Journal of Biomedical and Health Informatics 2022; 27(6): 2635-2646.
  • Manuel L, Fiz JA, Jane R. Estimation of instantaneous frequency from empirical mode decomposition on respiratory sounds analysis. 2013 IEEE 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2013.
  • Al-Naggar, NQ. A new method of lung sounds filtering using modulated least mean square-Adaptive noise cancellation. Journal of Biomedical Science and Engineering 2013; 6(9): 869-876.
  • Chang GC, Cheng YP. Investigation of noise effect on lung sound recognition. In 2008 IEEE International Conference on Machine Learning and Cybernetics, pp. 1298-1301, 2008.
  • Baharanchi SA, Vali M, Modaresi M. Noise reduction of lung sounds based on singular spectrum analysis combined with discrete cosine transform. Applied Acoustics 2022; 199: 109005.
  • Chang GC. A comparative analysis of various respiratory sound denoising methods. In 2016 IEEE International Conference on Machine Learning and Cybernetics (ICMLC) 2016, Jul 10, 2: 514-518.
  • Li L, Xu W, Hong Q, Tong F, Wu J. Adaptive noise cancellation and classification of lung sounds under practical environment. In 2016 IEEE 10th International Conference on Anti-counterfeiting, Security, and Identification (ASID), 2016 Sep 23, pp. 39-42.
  • Lu BY, Hsueh ML, Wu HD. Reducing the ambulance siren noise for distant auscultation of the lung sound. Acoustics Australia 2017; 45(2): 381-387.
  • Syahputra MF, Situmeang SI, Rahmat RF, Budiarto R. Noise reduction in breath sound files using wavelet transform based filter. In IOP Conference Series: Materials Science and Engineering 2017; 190: 012040.
  • Haider NS, Periyasamy R, Joshi D, Singh BK. Savitzky-Golay filter for denoising lung sound. Brazilian Archives of Biology and Technology 2018; 61: e18180203.
  • Meng F, Wang Y, Shi Y, Zhao H. A kind of integrated serial algorithms for noise reduction and characteristics expanding in respiratory sound. International Journal of Biological Sciences 2019; 15(9): 1921-1932.
  • Shi Y, Li Y, Cai M, Zhang XD. A lung sound category recognition method based on wavelet decomposition and BP neural network. International Journal of Biological Sciences 2019; 15(1): 195-207.
  • Singh D, Singh BK, Behera AK. Comparative analysis of lung sound denoising technique. In 2020 First International Conference on Power, Control and Computing Technologies (ICPC2T). IEEE, 2020.
  • Fava A, Dianat B, Bertacchini A, Manfredi A, Sebastiani M, Modena M, Pancaldi F. Pre-processing techniques to enhance the classification of lung sounds based on deep learning. Biomedical Signal Processing and Control 2024; 92: 106009.
  • Emmanouilidou D, McCollum ED, Park DE, Elhilali M. Computerized lung sound screening for pediatric auscultation in noisy field environments. IEEE Transactions on Biomedical Engineering 2017; 65(7): 1564-1574.
  • Emmanouilidou D, McCollum ED, Park DE, Elhilali M. Adaptive noise suppression of pediatric lung auscultations with real applications to noisy clinical settings in developing countries. IEEE Transactions on Biomedical Engineering 2015; 62(9): 2279-2288.
  • Dinis J, Campos G, Rogrigues J, Marques A. Respiratory sound annotation software. In Proceedings of the International Conference on Health Informatics (HEALTHINF-2012), pp. 183-188, 2012.
  • Fu-Shun H, Huang CJ, Kuo CY, Huang SR, Cheng YR, Wang JH, Wu YL, Tzeng TL, Lai F. Development of a respiratory sound labeling software for training a deep learning-based respiratory sound analysis model. International Forum on Medical Imaging in Asia 2021. Proceedings Volume 11792. SPIE, 2021.
  • Wanasinghe T, Bandara S, Madusanka S, Meedeniya D, Bandara M, de la Torre Diaz I. Lung sound classification with multi-feature integration utilizing lightweight CNN model. IEEE Access 2024; 12: 21262-21276.
  • Wanasinghe T, Bandara S, Madusanka S, Meedeniya D, Bandara M, de la Torre Díez I. Lung sound classification for respiratory disease identification using deep learning: a survey. International Journal of Online & Biomedical Engineering 2024; 20(9): 115-129.
  • Topaloglu I, Barua PD, Yildiz AM, Keles T, Dogan S, Baygin M, Gul HF, Tuncer T, Tan RS, Acharya UR. Explainable attention ResNet18-based model for asthma detection using stethoscope lung sounds. Engineering Applications of Artificial Intelligence 2023; 126: 106887.
  • Lo Giudice M, Mammone N, Ieracitano C, Aguglia U, Mandic D, Morabito FC. Explainable deep learning classification of respiratory sound for telemedicine applications. International Conference on Applied Intelligence and Informatics. Cham: Springer Nature Switzerland, 2022.
  • Mercaldo F, Brunese L, Cesarelli M, Martinelli F, Santone A. Respiratory disease detection through spectogram analysis with explainable deep learning. 2023 IEEE 8th International Conference on Smart and Sustainable Technologies (SpliTech), 2023.
  • Li L, Fan Y, Tse M, Lin KY. A review of applications in federated learning. Computers & Industrial Engineering 2020; 149: 106854.
  • Yang Q, Liu Y, Cheng Y. Kang Y, Chen T, Yu H. Federated Learning. Springer Link, 2019.
  • Le S, Wu J. A scalable and transferable federated learning system for classifying healthcare sensor data. IEEE Journal of Biomedical and Health Informatics 2022; 27(2): 866-877.
  • Gafni T, Shlezinger N, Cohen K, Eldar YC, H. V. Poor HV. Federated learning: A signal processing perspective. IEEE Signal Processing Magazine 2022; 39(3): 14-41.
  • Ykhlef H, Ykhlef F, Chiboub S. Experimental design and analysis of sound event detection systems: case studies. 2019 IEEE 6th International Conference on Image and Signal Processing and their Applications (ISPA), 2019.
  • Andreu-Perez J, Poon CCY, Merrifield RD, Wong STC, Yang GZ. Big data for health. IEEE Journal of Biomedical and Health Informatics 2015; 19(4): 1193-1208.
  • Kocheturov A, Pardalos PM, Karakitsiou A. Massive datasets and machine learning for computational biomedicine: trends and challenges. Annals of Operations Research 2019; 276: 5-34.