Title: Variation of the Spiking Dynamics of a Hodgkin-Huxley Neuron with an Electrical Autaptic Connection Under Ion Channel Blocking

Abstract: In this paper, we investigate how the blockage of potassium and sodium ion channels embedded in membranes affects the spiking dynamics of a Hodgkin-Huxley neuron model owing autaptic connection. We consider an electrical autapse expressed by its coupling strength and delay time. It is found that the spiking behavior of the neuron becomes more ordered with the increment of autaptic conductace regardless of the ion channel block level. Furthermore, it is obtained that the blockage of potassium and sodium ion channels influences differently to the spiking regularity of the neuron. Potassium ion channel blockage promotes regularity, whereas sodium ion channel blockage destroys.

Keywords: Electrical autapse; ion channel block; Hogkin-Huxley neuron model

Başlık: Elektriksel Öz-sinapstik Bağlantılı Bir Hodgkin-Huxley Nöronunun Ateşleme Dinamiklerinin İyon Kanal Bloklama Durumunda Değişimi

Özet: Bu çalışmada hücre zarında gömülü olan potasyum ve sodyum iyon kanallarının bloklanmasının öz-sinaptik bağlantıya sahip bir Hodgkin-Huxley nöronunun ateşleme dinamiklerinin nasıl etkilediği araştırılmıştır. Çalışmada, iletim gecikmesi ve kuplaj şiddetiyle tanımlanan bir elektriksel öz-sinaps durumu ele alınmıştır. İyon kanal durumuna bakılmaksızın, nöronun ateşleme davranışının öz-sinaptik iletkenliğindeki artışla daha düzenli hale geldiği tespit edilmiştir. Bunun yanı sıra, potasyum ve sodyum iyon kanallarının bloklamasının nöronun ateşleme dinamikleri üzerinde farklı etkilerinin olduğu tespit edilmiştir. Potasyum iyon kanal bloklamasının düzenliliği arttırırken, sodyum iyon kanal bloklaması ise düzenliliği bozmaktadır.

Anahtar kelimeler: Elektriksel öz-sinaps; iyon kanal bloklama; Hodgkin-Huxley nöron modeli

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