Title: pyNeuroSim: Python-Based Neuron Simulator

Abstract: The action potential of the neuron membrane corresponds to the biophysiological process of communication among neurons that make up the nervous system. It involves the transmission of information received from other neighboring cells and the external environment. Mathematical models have been developed to observe the formation and transmission of the action potential by tracking changes in the neuron membrane potential. One widely used mathematical model in neuroscience is the Hodgkin-Huxley Neuron Model. Programs have been created to simulate neural transmission using these mathematical models. The main purpose of this study is to develop a user-friendly computational program that provides an accessible and simple interface to understand the Hodgkin-Huxley neuron model computation with the forward Euler method. The program's structure allows users to modify the parameters that affect their membrane potential.

Keywords: Nöron modeli; aksiyon potansiyeli; simülator; Python

Başlık: pyNeuroSim: Python-Based Neuron Simulatörü

Özet: Sinir sistemini oluşturan nöronların; birbirleri ile iletişimi, diğer komşu hücreler ve dış çevreden aldıkları bilgilerin aktarılmasının biyofizyolojik sürecine nöron membranın aksiyon potansiyeli karşılık gelir. Nöron membran potansiyelindeki değişimi dolasıyla aksiyon potansiyelinin oluşması ve iletimini gözlemlemeye olanak sağlayan matematiksel modeller geliştirilmiştir. Bu çalışmada, matematiksel modellerden birisi olan ve sinirbilim alanında oldukça yaygın olarak kullanılan Hodgkin-Huxley nöron modeli kullanılmıştır. Nöronal iletimini inceleyebilmek adına bu geliştirilen matematiksel modelleri kullanarak simüle eden programlar oluşturulmuştur. Bu çalışmanın temel amacı erişilebilir, basit arayüzlü ve kolay anlaşılabilir bir eğitim programı sunmaktır. Bu amaç doğrultusunda Hodgkin-Huxley nöron modelinin ileri Euler yöntemi ile hesaplaması Python ortamına aktarılmış ve gerçekleştirilen programda kullanıcının membran potansiyeli üzerinde etki eden parametreleri değiştirmeye imkân tanıyan yapılar oluşturulmuştur.

Anahtar kelimeler: Neuron model; action potential; simulator; Python

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