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AKILLI SİSTEMLER VE UYGULAMALARI DERGİSİ
JOURNAL OF INTELLIGENT SYSTEMS WITH APPLICATIONS
J. Intell. Syst. Appl.
E-ISSN: 2667-6893
Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Human Mesenchymal Stem Cells Osteogenic Differentiation on Dental Barrier Membrane

İnsan Mesenkimal Kök Hücrelerinin Dental Bariyer Membran Üzerinde Osteojenik Farklılaşması

How to cite: Utar B, Sunal G, Pulat G, Karaman O. Human mesenchymal stem cells osteogenic differentiation on dental barrier membrane. Akıllı Sistemler ve Uygulamaları Dergisi (Journal of Intelligent Systems with Applications) 2022; 5(1): 55-58. DOI: 10.54856/jiswa.202205206

Full Text: PDF, in English.

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Title: Human Mesenchymal Stem Cells Osteogenic Differentiation on Dental Barrier Membrane

Abstract: In the field of tissue engineering, there are biodegradable bone implants with biocompatible synthetic polymers that provide successful results in many areas. Dental barrier membranes are bioabsorbable polylactide (PLA) membranes designed for use in many applications of guided bone regeneration (GBR). It provides a structure designed to attract, capture and retain fibroblasts and epithelial cells while protecting the area around the tooth for the development of bone and periodontal supporting tissue. The aim of this study was to evaluate the properties of dental barrier membranes that inhibit cell migration and promote bone formation differentiation using bone marrow stem cells (BMSCs) with high differentiation and proliferation properties. As a result of the study, characterization studies and cell viability experiments of the Synthetic Barrier Membrane product were carried out, and it was observed that it had a positive effect on the adherence and viability of the BMSCs.

Keywords: Dental barrier membrane; Bone marrow mesenchymal stem cell (BMSC); Bone regeneration


Başlık: İnsan Mesenkimal Kök Hücrelerinin Dental Bariyer Membran Üzerinde Osteojenik Farklılaşması

Özet: Doku mühendisliği alanında birçok alanda başarılı sonuçlar veren biyouyumlu sentetik polimerlere sahip biyobozunur kemik implantları bulunmaktadır. Dental bariyer membranlar, kılavuzlu kemik rejenerasyonunun (KKR) birçok uygulamasında kullanım için tasarlanmış biyolojik olarak emilebilir polilaktid (PLA) membranlardır. Kemik ve periodontal destek dokusunun gelişimi için dişin etrafındaki alanı korurken fibroblastları ve epitel hücrelerini çekmek, yakalamak ve tutmak için tasarlanmış bir yapı sağlar. Bu çalışmanın amacı, yüksek farklılaşma ve çoğalma özelliklerine sahip kemik iliği kök hücreleri (BMSC'ler) kullanılarak hücre göçünü önleyen ve kemik oluşumu farklılaşmasını destekleyen dental bariyer membranlarının özelliklerini değerlendirilmesidir. Çalışma neticesinde, Sentetik Bariyer Membran ürünün karakterizasyon çalışmaları ve hücre canlılık deneyi yürütülerek, kemik iliği kök hücresinin tutunumu ve canlılığına pozitif etki ettiği gözlemlenmiştir.

Anahtar kelimeler: Dental bariyer membran; Kemik iliği kök hücresi; Kemik rejenerasyonu


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