Title: Electrospun Nanofibers on Applications of Nerve Guide Channel

Abstract: Therapeutic methods developed for the repair of damaged nerves often do not provide adequate recovery. Along with the application of tissue engineering principles in the nerve tissue regeneration, many researches have been made and are still in progress to develop an ideal nerve guide channel. Promising studies are ongoing for the use of nano-sized fibrous scaffolds for nerve tissue repair, which can mimic the topography of the natural extracellular matrix. With the electrospinning method, nanofibers can be produced and the nanofiber nerve channels enabling neuron development and regrowth can be placed in the nerve gap that has lost its function. This study summarizes nerve tissue engineering strategies and clinical practices, including biomaterials and tissue scaffold production techniques to produce a structure that allows neurons to adhere, multiply, and eventually form nerves.

Keywords: Electrospinning; nanofibers; nerve guide channel; nerve regeneration; peripheral nervous system

Başlık: Elektroeğrilmiş Nanoliflerin Sinir Kılavuz Kanalı Uygulamalarında Kullanımı

Özet: Hasarlı sinirlerin onarımı için geliştirilen tedavi edici yöntemler çoğu zaman yeterli iyileşme sağlayamamaktadır. Doku mühendisliği iskele geliştirme prensiplerinin sinir doku rejenerasyonunda uygulanması ile birlikte sinir doku hasarlarında kullanılabilecek ideal sinir kılavuz kanalı geliştirilmesi için birçok araştırma yapılmıştır ve yapılmaya devam edilmektedir. Doğal hücre dışı matrisin topografyasını çoğunlukla taklit edebilen nano boyutlu lifli yapı iskelelerinin sinir doku onarımı için kullanımı ile igili umut vaat eden çalışmalar sürdürülmektedir. Elektroeğirme yöntemi ile nano boyutlu çaplara sahip lifler üretilebilir ve nanofiber sinir kanalları, fonksiyonunu kaybetmiş sinir boşluğuna yerleştirilerek nöron gelişimini ve yeniden büyümeyi sağlayabilir. Bu çalışma, nöronların yapışmasına, çoğalmasına ve nihayetinde sinir oluşturmasına izin verecek bir yapının üretilmesi için uygun biyomalzemeler ile doku iskelesi üretim tekniklerini içeren sinir doku mühendisliği stratejilerini ve klinik uygulamalarını özetlemektedir.

Anahtar kelimeler: Elektroeğirme; nanofiberler; periferik sinir sistemi; sinir kılavuz kanalı; sinir rejenerasyonu

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