Flag Counter
AKILLI SİSTEMLER VE UYGULAMALARI DERGİSİ
JOURNAL OF INTELLIGENT SYSTEMS WITH APPLICATIONS
J. Intell. Syst. Appl.
E-ISSN: 2667-6893
Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Variation of the Spiking Dynamics of a Hodgkin-Huxley Neuron with an Electrical Autaptic Connection Under Ion Channel Blocking

Elektriksel Öz-sinapstik Bağlantılı Bir Hodgkin-Huxley Nöronunun Ateşleme Dinamiklerinin İyon Kanal Bloklama Durumunda Değişimi

How to cite: Uzun R, Özer M. Variation of the spiking dynamics of a hodgkin-huxley neuron with an electrical autaptic connection under ion channel blocking. Akıllı Sistemler ve Uygulamaları Dergisi (Journal of Intelligent Systems with Applications) 2019; 2(2): 115-118. DOI: 10.54856/jiswa.201912079

Full Text: PDF, in English.

Total number of downloads: 604

Title: Variation of the Spiking Dynamics of a Hodgkin-Huxley Neuron with an Electrical Autaptic Connection Under Ion Channel Blocking

Abstract: In this paper, we investigate how the blockage of potassium and sodium ion channels embedded in membranes affects the spiking dynamics of a Hodgkin-Huxley neuron model owing autaptic connection. We consider an electrical autapse expressed by its coupling strength and delay time. It is found that the spiking behavior of the neuron becomes more ordered with the increment of autaptic conductace regardless of the ion channel block level. Furthermore, it is obtained that the blockage of potassium and sodium ion channels influences differently to the spiking regularity of the neuron. Potassium ion channel blockage promotes regularity, whereas sodium ion channel blockage destroys.

Keywords: Electrical autapse; ion channel block; Hogkin-Huxley neuron model


Başlık: Elektriksel Öz-sinapstik Bağlantılı Bir Hodgkin-Huxley Nöronunun Ateşleme Dinamiklerinin İyon Kanal Bloklama Durumunda Değişimi

Özet: Bu çalışmada hücre zarında gömülü olan potasyum ve sodyum iyon kanallarının bloklanmasının öz-sinaptik bağlantıya sahip bir Hodgkin-Huxley nöronunun ateşleme dinamiklerinin nasıl etkilediği araştırılmıştır. Çalışmada, iletim gecikmesi ve kuplaj şiddetiyle tanımlanan bir elektriksel öz-sinaps durumu ele alınmıştır. İyon kanal durumuna bakılmaksızın, nöronun ateşleme davranışının öz-sinaptik iletkenliğindeki artışla daha düzenli hale geldiği tespit edilmiştir. Bunun yanı sıra, potasyum ve sodyum iyon kanallarının bloklamasının nöronun ateşleme dinamikleri üzerinde farklı etkilerinin olduğu tespit edilmiştir. Potasyum iyon kanal bloklamasının düzenliliği arttırırken, sodyum iyon kanal bloklaması ise düzenliliği bozmaktadır.

Anahtar kelimeler: Elektriksel öz-sinaps; iyon kanal bloklama; Hodgkin-Huxley nöron modeli


Bibliography:
  • DeFelice J. Introduction to Membrane Noise. Plenum Press, New York, 1981.
  • Steinmetz PN, Manwani A, Koch C, London M, Segev I. Subthreshold voltage noise due to channel fluctuations in active neuronal membranes. Journal of Computational Neuroscience 2000; 9(2): 133-148.
  • White JA, Rubinstein JT, Kay AR. Channel noise in neurons. Trends in Neurosciences 2000; 23(3): 131-137.
  • Schneidman E, Freedman B, Segev I. Ion channel stochasticity may be critical in determining the reliability and precision of spike timing. Neural Computation 1998; 10(7): 1679-1703.
  • Hille B. Ionic Channels of Excitable Membranes. Third edition, Sinauer Associates Inc., Sunderland, Massachusetts, USA, 1992.
  • Schmid G, Goychuk I, Hanggi P. Controlling the spiking activity in excitable membranes via poisoning. Physica A: Statistical Mechanics and its Applications 2004; 344(3): 665-670.
  • Schmid G, Goychuk I, Hanggi P. Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model. Physical Biology 2004; 1(1-2): 61-66.
  • Gong YB, Xu B, Ma XG, Han JQ. Effect of channel block on the collective spiking activity of coupled stochastic Hodgkin-Huxley neurons. Science in China Series B Chemistry 2008; 51(4): 341-346.
  • Ozer M, Perc M, Uzuntarla M. Controlling the spontaneous spiking regularity via channel blocking on Newman-Watts networks of Hodgkin-Huxley neurons. Europhysics Letters 2009; 86(4): 40008-40014.
  • Yilmaz E, Ozer M, Cavusoglu A. Impact of the ion channel blockage on the collective spiking regularity of a scale-free neuronal network. Procedia Technology 2012; 1: 199-204.
  • Uzuntarla M, Uzun R, Yilmaz E, Ozer M, Perc M. Noise-delayed decay in the response of a scale-free neuronal network. Chaos Solitons & Fractals 2013; 56: 202-208.
  • Uzun R, Ozer M, Perc M. Can scale-freeness offset delayed signal detection in neuronal networks? Europhysics Letters 2014; 105(6): 60002-6007.
  • Uzun R, Ozer M. Kanal bloklaminin ilk spayk latans zamani uzerindeki etkisi. In 23th IEEE Conference on Signal Processing and Communication Applications (SIU'2015), May 16-19, 2015, Malatya, Turkey.
  • Karabelas AB, Purpura DP. Evidence for autapse in the substantia nigra. Brain Research 1980; 200(2): 467-473.
  • Bekkers JM. Synaptic transmission: Functional autapses in the cortex. Current Biology 2003; 13(11): R433-R435.
  • Ikeda K, Bekkers JM. Autapses. Current Biology 2006; 16(9): R308.
  • Van der Loos H, Glaser EM. Autapses in neocortex cerebri: Synapses between a pyramidal cell's axon and its own dendrites. Brain Research 1972; 48: 355-360.
  • Ma J, Tang J. A review for dynamics in neurons and neuronal network. Nonlinear Dynamics 2017; 89: 1569-1578.
  • Bacci A, Huguenard JR. Enhancement of spike-timing precision by autaptic transmission in neocortical inhibitory interneurons. Neuron 2006; 49(1): 119-130.
  • Li Y, Schmid G, Hanggi P, Schimansky-Geier L. Spontaneous spiking in an autaptic Hodgkin-Huxley setup. Physical Review E 2010; 82: 061907.
  • Wang H, Ma J, Chen Y, Chen Y. Effect of an Autapse on the firing pattern transition in a bursting neuron. Communications in Nonlinear Science and Numerical Simulation 2014; 19(9): 3242-3254.
  • Yilmaz E, Ozer M. Delayed feedback and detection of weak periodic signals in a stochastic Hodgkin-Huxley neuron. Physica A: Statistical Mechanics and its Applications 2015; 421: 455-462.
  • Wang H, Chen Y. Response of autaptic Hodgkin-Huxley neuron with noise to subthreshold sinusoidal signals. Physica A: Statistical Mechanics and its Applications 2016; 462: 321-329.
  • Yilmaz E, Ozer M, Baysal V, Perc M. Autapse-induced multiple coherence resonance in single neurons and neuronal networks. Scientific Reports 2016; 6: 30914.
  • Uzun R, Ozer M. Effects of autapse and channel blockage on firing regularity in a biological neuronal network. Istanbul Univesity Journal of Electrical & Electronics Engineering 2017; 17(1): 3069-3073.
  • Hodgkin AL, Huxley AF. A quantative description of membrane current and its application to conduction and excitation in nerve. The Journal of Physiology 1952; 117(4): 500-544.
  • Fox RF. Stochastic versions of the Hodgkin-Huxley equations. Biophysical Journal 1997; 72(5): 2068-2074.